St. Joseph on the Brandywine Church was built in 1841 by DuPont Company stone masons. The ground was donated by Charles I. DuPont and the cost of construction was financed largely through loans and gifts from the DuPont Company and the DuPont family.
For eighty years the parish had a close relationship with the nearby mills. Parishioner's pew rents were collected by the pastor through DuPont Company payroll deductions.
When the mills closed, many parishioners left and by the 1930's it appeared that the church might be closed as well. It was saved when people began to move out of Wilmington and establish suburbs. Current parishioners, approximately 1,000 families, come from the entire suburban area.